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Binance Review 2018: Comprehensive Crypto Coin Exchange Binance is a Chinese cryptocurrency exchange. Binance was created after attracting funds via an ICO (Initial Coin Offering – creating a new digital asset, backed by the project. Changpeng Zhao, former CTO at OKCoin is currently at the helm of Binance. They are known for fast processing speeds coupled with an ability to process enormous numbers of transactions (1.4 million) each second. It’s been quickly gaining ground in market share cementing a place as a top 20 exchange in terms of volume. Binance transaction has reached a new level and currently score tenth place in the world. Binance offers a generous daily withdrawal limit. They don’t need identity confirmation when the per day remittance is within limit of 2 BTC. Binance Features Binance’s trading platform is web-based. Furthermore it offers two distinct trading layouts, a more simple one and a “Pro” version. Their ICO has created tokens named BNB that are traded on the exchange. They can also be used as a method of paying your trading fees, which will reduce them by 50%. Binance offers their own startup incubator platform as well. The trading functionality of the platform was of more interest so we focused on that for the purposes of this Binance review. Below is the “standard platform” look: Below is the advanced display: BINANCE Advantages Large Cryptocurrency Pairings Supported The competitive advantage of Binance’s platform is the ability to trade every major cryptocurrency pairing in existence. Coinbase and Gemini only offer trading of a handful of the larger market capitalization cryptos, whereas Binance allows users access to trade over 100 crypto coins. Low Fees AND LIMITS The fee structure is simple as well as being priced. There is a flat 0.10% fee on all trading. The 0.10% fee on trades is one basis point. If you were to buy a cryptocoin at 100 you’d have to sell it higher for 101 to profit. Ease of Setup Setting up an account is straight forward, similar to signing up for an account with other service providers. Another advantage is there is no lengthy waiting time, users are able to get setup and running within minutes. This is due to the fact that fiat is not accepted on the exchange. Binance Provides Significant Trading Volume Binance is currently the third largest exchange by cryptocurrency trading volume, according to coinmarketcap. At the time of writing, Binance’s volume was an astounding $5,441,711,452 in the last 24 hours! This volume demonstrates their users clear trust in the exchange, as well as the accessibility of the exchange and ease of transacting. This type of volume requires substantial servers and computational power. Wide Support of Cryptocurrencies No Verification Requirements Binance doesn’t require identity confirmation in instances when the per day remittance is within the limit of 2 BTC. The attractiveness of setting up an account with Binance may be greater for a user in a jurisdiction where certain exchanges choose not to allow new users because of restrictions imposed by that location’s governing regulatory bodies. Ease of Use You’re able to buy and sell crypto pairings with market or limit orders while specifying the amount or percentage you wish to trade for each transaction. BINANCE Disadvantages No Leveraged Margin Trading Margin trading is not available at Binance. Margin trading is a system which allows you to trade with more money than you actually have in your account. Your balance is then used as a guarantee to maintain your position open. No Fiat Functionality This has both advantages and disadvantages. Government fiat deposits are not currently enabled in Binance, instead this exchange focuses only on the digital side of things. Clients can deposit and withdraw the coins supported at the exchange. This means that you’re not able to deposit or withdraw in fiat currency, only cryptocurrency is supported. Relatively New Binance was started in only July 2017, according to this Reddit post. This is a major concern, as they don’t have a history. Despite all the good things people are saying on Reddit. it’s worth mentioning as many exchanges have come and gone. Binance appears to have a visible co-founder, unlike BTC-E. Conclusion Accessible option for obtaining Different Cryptocoins Binance is the most rapidly-growing and communally praised cryptocurrency exchange available. It’s China based location may spell issues in the future due to rumors of a “crackdown“. that currently accounts for a large amount of volume. Although Binance targets high frequency traders, it is quite useful for those getting beginning with altcoin trading. Their lack of fiat money deposits may be difficult to swallow for beginners, only supported cryptocurrencies may be deposited. Binance boasts a large number of various cryptocoins for trading. The main benefit is the ability convert between cryptocurrencies. For instance exchanges such as Coinbase and Gemini are more limited in the number of cryptocurrencies offered. The interface is also conducive to support shorter duration hold time day trading of cryptocurrencies if one were so inclined to deploy that strategy. Binance is an exchange worth looking into and integrating into crypto trading just for their large amount of supported crypto coins.

KUALA LUMPUR: Bebaskan minda. Itu pandangan Aktres Terbaik, Festival Filem Malaysia (FFM) 2007, Vanidah Imran apabila memperkatakan soal peluang artis senior mendapat watak utama dalam drama mahupun filem tempatan. The Most Important Number for Gilead Shareholders (GILD, ABBV) By Investopedia | May 12, 2015 — 11:34 AM EDT SHARE ADD TO WATCHLIST GILD Gilead Sciences Inc 77.38 -0.28% ABBV AbbVie Inc 96.63 +1.07% View Watchlist It's been nearly two weeks since biotech blue chip stock Gilead Sciences (NASDAQ: GILD) reported its first-quarter earnings results, but time hasn't changed the fact that it delivered an absolutely stunning report. Gilead knocks Q1 out of the park Gilead has risen to fame because of its hepatitis C duo of Sovaldi and Harvoni. Harvoni is geared toward the most common and toughest-to-treat form of the disease, genotype 1, while Sovaldi takes aim at the lesser common genotypes 2 & 3. These drugs provide what is an effective cure for HCV, knocking out detectable levels of the disease in 90% or more of patients in a majority of Gilead's clinical trials. Best of all, these oral HCV drugs were able to do this without the assistance of IV interferon, a therapy known to cause flu-like symptoms in patients. Thus, these drugs improved patient quality of life, and likely longevity as well. \ Source: Gilead Sciences. The fact that these drugs are revolutionary isn't lost on Gilead's results. For the quarter it generated $7.6 billion in revenue, up 52% from the $5 billion it produced during Q1 2014, and it was led primarily by HCV drug growth. Sovaldi, which had been used as a genotype 1 treatment prior to Harvoni's Oct. 2014 approval, generated $972 million in sales, down from $2.27 billion in the year-ago period. However, Harvoni, in its first full quarter, racked up a ridiculous $3.58 billion in sales, implying it has a genuine shot at challenging anti-inflammatory Humira for the top-selling drug of 2015. Combined, HCV drugs made up 61.5% of total product sales for Gilead in the first quarter. They are essentially the future by which Gilead will live and die. And a specific figure tied to these drugs is ultimately the most important number that Gilead shareholders need to be aware of. The most important number for Gilead shareholders Investors don't need to be too concerned with Gilead's total HCV sales, the number of patients it treats, or the overall market potential for its drugs. Don't get me wrong, these aren't useless data points. However, with only it and AbbVie's Viekira Pak on the market right now in the U.S., Gilead has a veritable sea of opportunity to help people affected by this disease. The World Health Organization estimates there are 180 million people worldwide with HCV, and the Centers for Diseases Control and Prevention adds that 3.2 million of them live in the U.S. In short, there's a molehill of opportunity for Gilead, and investors shouldn't get too caught up in Sovaldi or Harvoni's quarter-to-quarter total sales figures. Instead, what really matters is whether or not Gilead Sciences continues to significantly discount its pricey HCV therapies in order to keep its market share edge. Why this number matters In February, when Gilead announced that it would begin paying its first-ever quarterly dividend, the company announced sweeping discounts to its HCV drugs, geared at appeasing insurers and group payers who scoffed at Sovaldi's $1,000/pill price tag and Harvoni's even higher $1,125/pill price. For a standard 12-week treatment a patient and his insurer could be staring down an $84,000 to $94,500 wholesale cost. In response to these requests, and for a variety of reasons we'll get into in a moment, Gilead executives warned Wall Street and investors of gross to net adjustments of up to 46%, beginning in Q1 of 2015. This is a fancy way of saying discounts and other rebates on these drugs of up to 46%. Comparatively, gross to net adjustments for Sovaldi and Harvoni totaled only 22% in 2014. Bigger discounts could certainly boost sales of its HCV products, but it could come at the cost of its margins and profitability. The steeper Gilead discounts its HCV products, the more patients it'll need to treat on a year-over-year or quarter-over-quarter basis in order to grow its profits. As Gilead's CFO Robin Washington pointed out during the conference call, many of Gilead's gross to net discounts began after the first quarter had begun. In other words, the full impact of those gross to net discounts will be seen in the second quarter. Why Gilead is getting aggressive with its discounting Part of the reason that Gilead decided discounts were necessary is tied to the pressure from insurance companies and activist consumers described above. It's not uncommon for drugs in the U.S. to be priced comparably "out of the ballpark" compared to other countries such as India where price caps are put in place. This pricing disparity helps Gilead subsidize the sale of its HCV drugs in lesser-developed countries, but it also has the effect of angering its domestic consumers. However, there are two additional reasons that the cuts were deemed necessary. First, Gilead needs to remain price-competitive against AbbVie's Viekira Pak. When Viekira Pak was approved in December, it debuted with a wholesale price tag of roughly $83,300, a bit below Sovaldi, but notably lower than Harvoni's comparable $94,500, 12-week price tag. What made the difference for AbbVie and Viekira Pak was the ability to land a multi-year deal with one of the nation's largest pharmacy-benefit managers immediately following its approval. The deal secured Viekira Pak as the genotype 1 drug of choice with this particular PBM, but it came at the cost of a sizable discount to Viekira Pak for this PBM. The move also meant Gilead's HCV drugs would be dropped for the genotype 1 indication by this PBM. With worries mounting that AbbVie would secure additional deals, Gilead also began securing long-term deals with insurers and PBMs, whereby it offered discounts on its HCV drugs in return for exclusivity. The move appears to have worked in the meantime, with Gilead totaling $3.02 billion in U.S. Harvoni sales in Q1 compared to the $138 million that Viekira Pak generated within the United States. It also doesn't hurt that, from a standpoint of convenience, Harvoni and Sovaldi are a once-daily pill. Viekira Pak involves taking up to six pills daily. The other key reason for aggressive discounting is European austerity measures. As Gilead states in its "forward-looking statements" section of its Q1 report, "The potential for additional austerity measures in European countries... may increase the amount of discount required on Gilead's products." To be clear, this isn't HCV-specific, and it speaks to Gilead's entire pipeline. However, Europe remains a key market for Harvoni and Sovaldi, so ensuring that each country's regulating body includes these drugs on the approved reimbursement list is critical to Gilead's success. Where's Gilead stock headed next? I can't say I'm a huge fan of how steeply Gilead is having to discount its products in the wake of AbbVie entering the market and do remain a bit concerned with what might happen when additional players enter the field either this year or the next. Still, it's difficult to overlook Gilead's market share dominance in the U.S., arguably the most prized market, even with its discounting. A forward P/E below 10 and what's shaping up to be a decade-long, or longer, opportunity to help HCV patients makes me believe that Gilead's stock has more left in the tank. The only reason I can surmise that its share price has stalled over the past few months relates to the uncertainties surrounding its discounting. Once investors adjust to the new norm, Gilead may once again start moving higher. This $19 trillion industry could destroy the Internet One bleeding-edge technology is about to put the World Wide Web to bed. And if you act right away, it could make you wildly rich. Experts are calling it the single largest business opportunity in the history of capitalism... The Economist is calling it "transformative"... But you'll probably just call it "how I made my millions." Don't be too late to the party -- click here for one stock to own when the Web goes dark. Sean Williams has no material interest in any companies mentioned in this article. Copyright © 1995 - 2015 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy. Read more: The Most Important Number for Gilead Shareholders (GILD, ABBV) | Investopedia https://www.investopedia.com/stock-analysis/051215/most-important-number-gilead-shareholders-gild-abbv.aspx#ixzz5LEpMcOBv Follow us: Investopedia on Facebook

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