Binance Review 2018: Comprehensive Crypto Coin Exchange
Binance is a Chinese cryptocurrency exchange. Binance was created after attracting funds via an ICO (Initial Coin Offering – creating a new digital asset, backed by the project. Changpeng Zhao, former CTO at OKCoin is currently at the helm of Binance. They are known for fast processing speeds coupled with an ability to process enormous numbers of transactions (1.4 million) each second. It’s been quickly gaining ground in market share cementing a place as a top 20 exchange in terms of volume.
Binance transaction has reached a new level and currently score tenth place in the world. Binance offers a generous daily withdrawal limit. They don’t need identity confirmation when the per day remittance is within limit of 2 BTC.
Binance Features
Binance’s trading platform is web-based. Furthermore it offers two distinct trading layouts, a more simple one and a “Pro” version.
Their ICO has created tokens named BNB that are traded on the exchange. They can also be used as a method of paying your trading fees, which will reduce them by 50%. Binance offers their own startup incubator platform as well. The trading functionality of the platform was of more interest so we focused on that for the purposes of this Binance review.
Below is the “standard platform” look:
Below is the advanced display:
BINANCE Advantages
Large Cryptocurrency Pairings Supported
The competitive advantage of Binance’s platform is the ability to trade every major cryptocurrency pairing in existence. Coinbase and Gemini only offer trading of a handful of the larger market capitalization cryptos, whereas Binance allows users access to trade over 100 crypto coins.
Low Fees AND LIMITS
The fee structure is simple as well as being priced. There is a flat 0.10% fee on all trading. The 0.10% fee on trades is one basis point. If you were to buy a cryptocoin at 100 you’d have to sell it higher for 101 to profit.
Ease of Setup
Setting up an account is straight forward, similar to signing up for an account with other service providers. Another advantage is there is no lengthy waiting time, users are able to get setup and running within minutes. This is due to the fact that fiat is not accepted on the exchange.
Binance Provides Significant Trading Volume
Binance is currently the third largest exchange by cryptocurrency trading volume, according to coinmarketcap. At the time of writing, Binance’s volume was an astounding $5,441,711,452 in the last 24 hours! This volume demonstrates their users clear trust in the exchange, as well as the accessibility of the exchange and ease of transacting. This type of volume requires substantial servers and computational power.
Wide Support of Cryptocurrencies
No Verification Requirements
Binance doesn’t require identity confirmation in instances when the per day remittance is within the limit of 2 BTC. The attractiveness of setting up an account with Binance may be greater for a user in a jurisdiction where certain exchanges choose not to allow new users because of restrictions imposed by that location’s governing regulatory bodies.
Ease of Use
You’re able to buy and sell crypto pairings with market or limit orders while specifying the amount or percentage you wish to trade for each transaction.
BINANCE Disadvantages
No Leveraged Margin Trading
Margin trading is not available at Binance. Margin trading is a system which allows you to trade with more money than you actually have in your account. Your balance is then used as a guarantee to maintain your position open.
No Fiat Functionality
This has both advantages and disadvantages. Government fiat deposits are not currently enabled in Binance, instead this exchange focuses only on the digital side of things. Clients can deposit and withdraw the coins supported at the exchange. This means that you’re not able to deposit or withdraw in fiat currency, only cryptocurrency is supported.
Relatively New
Binance was started in only July 2017, according to this Reddit post. This is a major concern, as they don’t have a history. Despite all the good things people are saying on Reddit. it’s worth mentioning as many exchanges have come and gone. Binance appears to have a visible co-founder, unlike BTC-E.
Conclusion
Accessible option for obtaining Different Cryptocoins
Binance is the most rapidly-growing and communally praised cryptocurrency exchange available. It’s China based location may spell issues in the future due to rumors of a “crackdown“. that currently accounts for a large amount of volume. Although Binance targets high frequency traders, it is quite useful for those getting beginning with altcoin trading. Their lack of fiat money deposits may be difficult to swallow for beginners, only supported cryptocurrencies may be deposited. Binance boasts a large number of various cryptocoins for trading.
The main benefit is the ability convert between cryptocurrencies. For instance exchanges such as Coinbase and Gemini are more limited in the number of cryptocurrencies offered. The interface is also conducive to support shorter duration hold time day trading of cryptocurrencies if one were so inclined to deploy that strategy. Binance is an exchange worth looking into and integrating into crypto trading just for their large amount of supported crypto coins.
MOSCOW: Selepas sebulan dan 63 perlawanan, Piala Dunia 2018 mencapai kemuncak dengan Perancis yang dibarisi skuad muda dan ditunjangi Kylian Mbappe serta Antoine Griezmann memburu trofi keagungan bola sepak itu buat kali kedua, esok.
Mesothelioma Chemotherapy
Mesothelioma Chemotherapy
Chemotherapy is one of the most commonly used treatments for cancer. The standard first-line chemotherapy treatment for mesothelioma is pemetrexed (Alimta®) and Cisplatin. Some recent studies show that combining these drugs with bevacizumab (Avastin) can improve the effectiveness of chemotherapy against mesothelioma.
Chemotherapy (literally “chemical therapy”) is the use of certain medications to kill cancer cells and prevent them from multiplying. A number of different chemotherapy drugs are available to treat mesothelioma, although some of these drugs have proven to be more successful than others.
How Chemotherapy Treats Mesothelioma
Chemotherapy can be used to treat mesothelioma patients in two ways. Either or both of these methods may be used in conjunction with surgery and/or radiation, depending on the treatment plan developed by the doctor and the patient.
Systemic ChemotherapyIntraoperative Chemotherapy
Systemic Chemotherapy
Chemotherapy can be given intravenously or as a pill. It then travels throughout the bloodstream and reaches the entire body. Systemic chemotherapy carries the most side effects because in addition to killing cancer cells, it also kills other fast-growing cells such as hair and blood cells.
First-Line and Second-Line Chemotherapy
Chemotherapy treatments are often discussed as being first-line and second-line (or even third-line) treatments. These refer to the chemotherapy treatments given first, second, third, and so on, based on their effectiveness.
The most common first-line treatment for mesothelioma is a combination – often called a “cocktail” – of pemetrexed and a platinum-based drug such as cisplatin or carboplatin. This combination has been found to be the most effective in treating mesothelioma, and therefore, it is usually administered first.
If the first-line treatment does not work, a second-line treatment may be tried. There is currently no consensus within the medical community about the best second-line treatment for mesothelioma. Doctors will often make their best decision on which drugs can best treat the disease based on the patient’s specific circumstances.
Mesothelioma Chemotherapy Drugs
A number of different chemotherapy drugs can be used to treat mesothelioma. The recommended chemotherapy drug will vary with each patient. Oncologists choose the drugs they believe will most benefit the patient while also taking into consideration side effects and other important issues.
Currently, the most widely used drug and the one with which doctors have had the most success is Pemetrexed (Alimta®). This drug is usually used in tandem with a platinum agent like Cisplatin and has been shown to add several months to the patient's mesothelioma life expectancy in many cases.
Have a Question About Chemotherapy and Mesothelioma?
Annette Charlevois is happy to help
Pemetrexed (Alimta®)
Pemetrexed is the most common chemotherapy drug used to treat mesothelioma, often given in conjunction with cisplatin. It is an injected drug, and patients will often be given corticosteroids and prescribed vitamin B9 (folic acid) and B12 supplements to prevent certain harmful side effects.
Cisplatin
Cisplatin is a platinum-based chemotherapy drug administered through an IV. Along with pemetrexed, it is one of the most common mesothelioma drugs. In many cases, doctors will treat mesothelioma patients with cisplatin for unresectable tumors (i.e., when surgery is not an option).
Carboplatin
Another platinum-based drug, carboplatin was derived from cisplatin in the 1980s. Although it typically has fewer and milder side effects than cisplatin, it can also inhibit the body’s production of blood cells, leading to an increased likelihood of fatigue and infection.
Gemcitabine (Gemzar)
Typically administered in combination with carboplatin, gemcitabine is used to treat lung, bladder, and ovarian cancers. In clinical trials, it has been shown to be a relatively effective chemotherapy treatment for mesothelioma, and is often used as a second-line treatment.
Ranpirnase (Onconase)
Granted orphan drug status by the FDA in 2007, ranpirnase is an enzyme that has been shown in clinical trials to effectively kill mesothelioma cells by breaking down their RNA. It is unique in that it does this without affecting healthy cells, which severely reduces the potential side effects of chemotherapy.
Vinorelbine (Navelbine)
Primarily used to treat non-small-cell lung cancer (NSCLC), vinorelbine has also been shown to be somewhat effective against mesothelioma. It works by triggering apoptosis (programmed cell death) in cancer cells.
Other chemo drugs used to treat mesothelioma patients include vinorelbine, mitomycin and raltitrexed. These are generally used in combinations but may be used alone if the patient is unable to tolerate two drugs.
The recommended chemotherapy drug will vary with each patient. Oncologists choose the drugs they believe will most benefit the patient while also taking into consideration side effects and other important issues surrounding the use of chemotherapy. It may take more than one try to discover which drugs will be best suited to the patient.
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Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Another option which has been proven highly effective in treating peritoneal mesothelioma that has not metastasized outside of the abdomen is Hyperthermic Intraperitoneal Chemotherapy (HIPEC). This procedure combines surgery with a concentrated dose of chemotherapy in the abdomen with minimal exposure to the rest of the body.
Following a peritonectomy and/or cytroreductive surgery to remove parts of the peritoneum and any visible tumors in the abdomen, a heated chemotherapy solution is introduced into the abdominal cavity. After the roughly 100-103 degree solution is pumped into the abdomen, it circulates for one and half to two hours reaching all exposed areas aiming to kill any cancer cells that may not have been removed during surgery. This procedure is beneficial as it allows for a more concentrated dose of chemotherapy while not subjecting the rest of the body to the potential toxic effects of the drug.
Speak with a MESOTHELIOMA SURVIVOR
Von St. James FamilyCONNECT WITH HEATHER
Coordinate a time to speak with Heather Von St. James.
Learn Firsthand About:
Heather’s Amazing Story
Dr. David Sugarbaker’s Successful Treatment Approach
Life After Surviving a Mesothelioma Diagnosis
Coping Strategies for Patients & Family Members
Side Effects of Chemotherapy
Chemotherapy can cause many side effects in mesothelioma patients. Most of these adverse effects are short term and will go away soon after treatment ends. Others, however, can last long time, in some cases even years after the chemotherapy has ended.
Patients or their loved ones should report all chemotherapy side effects to the patient’s medical team, even if they are deemed “common” or seem mild. This is especially important after the first treatment, when it may be difficult to predict how the patient will react to certain drugs.
Most Common Chemotherapy Side Effects Checklist Icon
Chemo Brain
Characterized by memory loss and an inability to focus or multitask, this condition is reported by a large number of mesothelioma patients who receive chemotherapy. While there is no “cure” for chemo brain, it can often be managed through exercise, a healthy diet, and routines that help patients organize their daily life.
Hair Loss
Many types of chemotherapy kills all types of fast-growing cells, which includes hair. As a result, a mesothelioma patient’s hair may fall out all over the body, not just on the head. Note, however, that not all types of chemotherapy cause hair loss, and each individual’s reaction may be different.
Mouth Sores
Also called mucositis, chemotherapy can cause an inflammatory reaction of the mucous lining in the upper gastrointestinal tract, causing sores in the mouth, lips, throat, and surrounding tissue. As one of the most painful side effects of chemo, these sores can interfere with nutrition by making it difficult to chew or swallow and affecting taste. While these mouth sores cannot be prevented, they can be managed through pain medications.
Nausea/Vomiting
Patients are often given an antiemetic drug before chemotherapy sessions to lessen the chance of stomach distress. Inform your doctor if nausea gets out of hand and lasts more than a day or two, or if it interferes with your ability to eat. Many newer chemotherapy drugs are less likely to cause nausea and vomiting than older drugs.
Low Blood Cell Counts
Fast-growing blood cells, including both red and white blood cells, can be killed by chemotherapy, which can compromise the body’s immune response and reduce the flow of oxygen to parts of the body. This can lead to an increased potential for infection, easy bruising and bleeding, and fatigue.
Receiving Treatment
Chemotherapy is generally given intravenously or it may also be administered in pill form. This type of chemo is called “systemic” chemotherapy—it travels through the blood stream and reaches the entire body. Systemic chemotherapy carries the most side effects because it not only does the job it is meant to do—kill fast-growing cancer cells—but, unfortunately, it also kills other kinds of fast-growing cells such as hair and blood cells. Hence, many people undergoing chemotherapy treatment will lose their hair and suffer low white or red blood cell counts.
Some pleural mesothelioma patients may be candidates for a different kind of chemotherapy that more closely targets the tumor and causes fewer side effects. Known as intrapleural chemotherapy, this method involves infusing drugs via a catheter into the chest area—the site of the primary tumor. This intracavitary chemotherapy treatment has proven to be most successful in treating cancers that are still limited to just the pleural surface. A similar procedure is available for those who suffer from peritoneal mesothelioma.
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